Konkurs ofert na lokal użytkowy – pływalnia Orka – Miejski Ośrodek Sportu i Rekreacji w Radomiu

Miejski Ośrodek Sportu i Rekreacji w Radomiu ogłasza konkurs ofert na dzierżawę lokalu użytkowego 26 m2 zlokalizowanego na obiekcie „Orka” przy ul. Młynarskiej w Radomiu. Osoby zainteresowane składaniem oferty odsyłamy do szczegółów w TYM PLIKU.

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Tesamorelin is a synthetic growth hormone releasing peptide that is administered
by subcutaneous injection. It works by stimulating the pituitary gland to
release endogenous growth hormone, which in turn increases levels of insulin‑like growth factor 1 (IGF‑1).
The drug has been specifically approved for the treatment of excess abdominal fat in HIV‑infected adults with lipodystrophy and is marketed in the United States under the brand name Egrifta.

Subcutaneous Route

The standard dosing regimen for Tesamorelin involves a daily injection of 2 mg delivered subcutaneously.
The injection is typically given once per day, preferably at the same time each morning, using a pre‑filled
pen or syringe. Because the drug is administered under the skin,
patients are trained to rotate injection sites—commonly the abdomen, thighs, or upper arms—to reduce local
irritation and maintain absorption efficiency. Patients should be instructed to clean the site with an alcohol swab before
injecting, avoid pressing on the area after injection, and store unused pens at room temperature.

Research Overview

Clinical trials have examined Tesamorelin’s safety profile in various patient populations.
Phase III studies demonstrated a significant reduction in visceral adipose tissue volume
among HIV‑positive patients, while secondary outcomes included
improvements in insulin sensitivity markers such as fasting glucose and HOMA‑IR scores.
A large, multicenter trial also evaluated the drug’s effects on cardiovascular risk factors; results indicated modest improvements in lipid profiles but did not
reach statistical significance for all endpoints.

Beyond its approved indication, research has explored Tesamorelin in aging populations to counteract sarcopenia
and frailty. Small pilot studies reported increases in lean body mass and muscle strength after 12
weeks of therapy, though larger randomized trials
are needed to confirm efficacy and safety. Additionally, investigations into the combination of Tesamorelin with other growth hormone
secretagogues, such as Ipamorelin, have suggested potential synergistic effects on IGF‑1 production; however,
data remain preliminary.

United States Brand Name

In the United States, Tesamorelin is marketed by Janssen Pharmaceuticals under the brand name Egrifta.
The product labeling includes detailed prescribing information, contraindications,
and a comprehensive list of known adverse reactions observed during
clinical development and post‑marketing surveillance.

Common Side Effects

The most frequently reported side effects of Tesamorelin include:

Injection site reactions – pain, redness, swelling, or itching at
the needle insertion point.

Edema – mild to moderate fluid retention, often presenting
as swelling in the hands, feet, or face.

Hypersensitivity reactions – rash, pruritus,
and in rare cases anaphylaxis have been documented; patients are advised to seek
immediate medical attention if symptoms develop.

Hyperglycemia – elevations in fasting glucose levels may
occur due to growth hormone’s anti‑insulin effects;
monitoring is recommended for diabetic or prediabetic individuals.

Headache and dizziness – reported by a subset of users, typically
mild and transient.

Joint pain or arthralgia – some patients experience discomfort in the knees or
hips.

These side effects are generally mild to moderate in severity
and tend to resolve with continued therapy or
dose adjustment.

Serious Adverse Events

Although rare, serious adverse events have
been documented:

Severe hypersensitivity – anaphylactic reactions requiring epinephrine administration.

Excessive edema leading to pulmonary congestion – particularly in patients with underlying
cardiac disease.

Elevated IGF‑1 levels – which could theoretically increase the risk of malignancy, though no definitive causal link has been established in long‑term
studies.

Hypertension – transient increases in blood pressure have been observed
in some subjects.

Patients with a history of hypersensitivity to peptides or those on concurrent medications
that may affect glucose metabolism should be monitored closely.

Drug Interactions

Tesamorelin can interact with other agents affecting growth hormone pathways.

For instance, exogenous insulin therapy might exacerbate hyperglycemia when combined with Tesamorelin’s anti‑insulin action. Additionally,
the use of glucocorticoids may blunt IGF‑1 production, potentially reducing
therapeutic efficacy. Careful coordination with a healthcare provider is advised before initiating or adjusting
concomitant medications.

Monitoring Recommendations

During therapy, clinicians typically recommend:

Baseline and periodic fasting glucose measurements to detect hyperglycemia early.

Serum IGF‑1 levels at baseline and after 12
weeks to assess pharmacodynamic response and adjust dosing
if necessary.

Physical examination of injection sites for signs of inflammation or infection.

Assessment of edema through patient self‑reporting and clinical evaluation, particularly in the first few
months of treatment.

Regular follow‑up visits are essential to
balance therapeutic benefits with potential adverse effects.

Patient Education

Patients should be informed about:

The importance of maintaining a consistent injection schedule.

Proper hand hygiene and site rotation techniques.

Recognition of early signs of severe allergic reactions such as swelling of the lips, throat, or difficulty breathing.

Symptoms of hyperglycemia (polyuria, polydipsia, blurred vision)
that warrant prompt medical attention.

Conclusion

Tesamorelin delivered subcutaneously has a well‑characterized side effect
profile dominated by local injection site issues, mild edema,
and metabolic changes such as transient hyperglycemia.
Serious adverse events are uncommon but can occur,
especially in patients with predisposing conditions. Ongoing research
continues to refine its therapeutic indications and safety parameters, particularly
when considered for off‑label uses or combined regimens with other growth
hormone secretagogues like Ipamorelin. The United States brand name Egrifta remains the primary vehicle through
which Tesamorelin is prescribed and monitored
in clinical practice.

References:

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